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  • z vad fmk In order to anonymize the data information on cent

    2018-11-07

    In order to anonymize the data, information on center-specific study and subject codes have been removed using an automated procedure described in [8]. All human participants were given integer IDs that are consistent across all other data releases of the studyforrest project [8].
    Experimental design, materials and methods Functional MRI data were recorded from seven healthy volunteers (age 21–38 years, 5 males) with normal or corrected to normal vision. The experiment had an event related design with each trial consisting of 3s of flickering grating display and 5s of medium gray. The random phase shifted sine wave gratings (0.8–7.6° eccentricity, 100% contrast, spatial frequency of 1.4 cycles per degree of visual angle, 125ms ON/OFF period) were independently oriented at either 0°, 45°, 90°, or 135°. There were 30 such trials in an experimental run. For every session 10 runs were acquired. For additional details on the procedures please refer to [14].
    Acknowledgements This research was supported by a grant from the German Research Foundation (DFG) awarded to S. Pollmann and O. Speck (DFG PO 548/15-1). M. Hanke was supported by funds from the German Federal State of Saxony-Anhalt and the European Regional Development Fund (ERDF), Project: Center for Behavioral Brain Sciences.
    Data The data presented here are values obtained from developing C57Bl/6 mice on P7 (prior to exposure), P14 (1-week post exposure), and P42-56 (5–7 weeks post exposure) with respect to sex. Specifically, z vad fmk weight- and brain volume-to-body weight ratios are demonstrated, steady-state levels of whole brain cell-specific protein content are shown, and quantification of neuronal density in the primary somatosensory neocortex and CA3 region of the hippocampus is presented (Figs. 1-3 and Tables 1-3).
    Experimental design, materials and methods
    Specifications Table
    Data
    Experimental design, materials and methods
    Acknowledgments This work was funded by grants from the Auditory Cognitive Neuroscience Society (ACN) to MB and SAK, the Natural Sciences and Engineering Research Council (NSERC) of Canada to SB (04686-15), and the Biotechnology and Biological Science Research Council (BBSRC) of the UK to SAK (BB/M009742/1).
    Specifications Table
    Value of the data
    Data The data reported include direct effects of rotenone (50–1000nM) on calcium retention capacity (CRC) in isolated control cortex and cerebellum mitochondria (Fig. 1). We also measured the effects of intravenous rotenone infusion (0.01mg/kg) on respiration rates (leak and phosphorylating) of isolated normal and 120min ischemia damaged cortex and cerebellum mitochondria respiring with substrates pyruvate/malate and succinate (Table 1) as well as original recording of respirometric curve of mitochondria is presented (Fig. 2). Effects of rotenone intravenous infusion (0.01mg/kg) on complex I (Fig. 3) and complex II (Fig. 4) activities of mitochondria isolated from control rat cortex and cerebellum and after 120min brain ischemia are shown. The detailed experimental procedures of isolation of brain cortex and cerebellum mitochondria, measurements of CRC, respiration, activities of respiratory chain complexes I and II and H2O2 generation in cortex and cerebellum mitochondria are described.
    Experimental design, materials and methods
    Data The dataset of this article provides the concentration of the metals and metalloids in the various products from the three different methods used to measure concentration (Tables S1, S2 andS3), along with the relative percent deviation of concentration measurements between the inductively-coupled plasma mass spectrometry and the inductively-coupled plasma triple quadrupole mass spectrometry analyses (Table S4) and the physico-chemico properties of each metal/metalloid used in the SkinPerm modeling (Table S5).
    Experimental design, materials and methods Each cosmetic sample was pre-screened for metal content with the use of an X-ray fluorescence analyzer. If there was any metal detected in a cosmetic then it was purchased in order to do further analysis. Each cosmetic sample purchased was analyzed a second time with the X-ray fluorescence analyzer in a controlled environment and the data is shown in Table S1. Twenty-six samples from those analyzed by X-ray fluorescence were randomly selected and sent to EMSL, Analytical Inc. (Cinnaminson, NJ, USA) where they were analyzed by inductively-coupled plasma mass spectrometry. A subset of ten samples, five eyeshadows and five body paints, were selected from those sent to EMSL Laboratory, and they were sent to Brooks Applied Labs, for additional testing by inductively-coupled plasma triple quadrupole mass spectrometry. The additional testing included analysis for 67 metals and metalloids, including Hg and methyl mercury (MeHg). The data from the inductively-coupled plasma mass spectrometry and inductively-coupled plasma triple quadrupole mass spectrometry, for the ten samples analyzed by both methods, are shown in Table S2 and Table S3, respectively. The relative percent deviation between the data from EMSL and Brooks Applied Labs are presented in Table S4. Finally, SkinPerm modeling was performed for each chemical to determine the average systemic absorption dose of each chemical. To perform the SkinPerm model, the physico-chemico parameters for each element were needed. These parameters are presented in Table S5. The SkinPerm model results can be found in [1].