• 2018-07
  • 2018-10
  • 2018-11
  • The treatment of KLS involves several medications


    The treatment of KLS involves several medications. However, there is no specific or effective therapy for the problem [3]. Among the stimulants, amantadine may possess significant effect upon the ending of a crisis at the beginning of the treatment, but it naloxone hydrochloride loses its efficacy with repeated use; modafinil, methylphenidate and amphetamine occasionally increase awareness, but do not improve the cognitive complaints [2,5]. Antidepressants such as bupropione and fluoxetine have limited effect upon cases with depressive behavior, but lack the prophylactic effect upon the disease [2,5]. Neuroleptics are not efficacious in treating the psychotic symptoms, de-realization and behavioral symptoms, although risperidone may act upon cases that are followed by delirium. Lithium and valproate might help to prevent the recurrence of this type of symptom [2,4,5]. Presently, the drug treatment does not help the patients with KLS. Very few improvements with this type of treatment have been reported [5]. Differential diagnoses like narcolepsy, no convulsive epileptic status[1,6], familiar hemiplegic migraine, hypothalamic tumors and psychiatric disorders must always be researched. In patients with KLS, OSA must always be included and treated for high prevalence in terms of weight gain in this population [6].